API reference
Bromfenac sodium hydrate
- CAS number
- 120638-55-3
- Molecular formula
- C30H28Br2N2Na2O9
- Molecular weight
- 766.3 g/mol
About this molecule
Bromfenac Sodium is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic administration, bromfenac binds to and inhibits the activity of cyclooxygenase II (COX II), an enzyme which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins (PG). By inhibiting PG formation, bromfenac is able to inhibit PG-induced inflammation, thereby preventing vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, an increase in vascular permeability and an increase in intraocular pressure (IOP).
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- disodium;bis(2-[2-amino-3-(4-bromobenzoyl)phenyl]acetate);trihydrate
- InChIKey
- PPOSVVJOVKVBPW-UHFFFAOYSA-L
- SMILES
- C1=CC(=C(C(=C1)C(=O)C2=CC=C(C=C2)Br)N)CC(=O)[O-].C1=CC(=C(C(=C1)C(=O)C2=CC=C(C=C2)Br)N)CC(=O)[O-].O.O.O.[Na+].[Na+]
- PubChem CID
- 11954316
Also known as
Bromfenac Sodium Sesquihydrate · BromSite · Bromday · Bromfenac monosodium salt sesquihydrate · Yellox · Prolensa · bromfenac 0.075% · BROMSITE 0.075%
Related entries in the range
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