API reference
Cobicistat on silicon dioxide
- CAS number
- 1004316-88-4
- Molecular formula
- C40H53N7O5S2
- Molecular weight
- 776 g/mol
About this molecule
Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic exposure of coadministered agents that are metabolized by CYP3A enzymes. More specifically, cobicistat is indicated to increase systemic exposure of atazanavir or darunavir (once daily dosing regimen) in combination with other antiretroviral agents in the treatment of HIV-1 infection. Increasing systemic exposure of anti-retrovirals (ARVs) without increasing dosage allows for better treatment outcomes and a decreased side effect profile.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- 1,3-thiazol-5-ylmethyl N-[(2R,5R)-5-[[(2S)-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-4-morpholin-4-ylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
- InChIKey
- ZCIGNRJZKPOIKD-CQXVEOKZSA-N
- SMILES
- CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5
- PubChem CID
- 25151504
Also known as
Cobicistat · Tybost · cobicistatum · COBICISTAT, (R,R,S)- · GENVOYA COMPONENT COBICISTAT · EVOTAZ COMPONENT COBICISTAT · SYMTUZA COMPONENT COBICISTAT · REZOLSTA COMPONENT COBICISTAT
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Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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