API reference
Isosorbide mononitrate
- CAS number
- 16051-77-7
- Molecular formula
- C6H9NO6
- Molecular weight
- 191.14 g/mol
About this molecule
Isosorbide Mononitrate is the mononitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide mononitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide mononitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05)
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- [(3S,3aR,6R,6aS)-3-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate
- InChIKey
- YWXYYJSYQOXTPL-SLPGGIOYSA-N
- SMILES
- C1[C@@H]([C@@H]2[C@H](O1)[C@@H](CO2)O[N+](=O)[O-])O
- PubChem CID
- 27661
Also known as
ISOSORBIDE MONONITRATE · Isosorbide 5-mononitrate · Imdur · Monosorbitrate · Isosorbide 5-nitrate · Corangin · Monoket · ISMN
Related entries in the range
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