API reference
Acenocoumarol
- CAS number
- 152-72-7
- Molecular formula
- C19H15NO6
- Molecular weight
- 353.3 g/mol
About this molecule
Acenocoumarol is a 4-hydroxycoumarin derivative with anticoagulant activity. As a vitamin K antagonist, acenocoumarol inhibits vitamin K epoxide reductase, thereby inhibiting the reduction of vitamin K and the availability of vitamin KH2. This prevents gamma carboxylation of glutamic acid residues near the N-terminals of the vitamin K-dependent clotting factors, including factor II, VII, IX, and X and anticoagulant proteins C and S. This prevents their activity and thus thrombin formation. Compared to other coumarin derivatives, acenocoumarol has a short half-life.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]chromen-2-one
- InChIKey
- VABCILAOYCMVPS-UHFFFAOYSA-N
- SMILES
- CC(=O)CC(C1=CC=C(C=C1)[N+](=O)[O-])C2=C(C3=CC=CC=C3OC2=O)O
- Other CAS numbers recorded
- 1185071-64-0
- PubChem CID
- 54676537
Also known as
Acenocoumarin · Nicoumalone · Sintrom · Nitrowarfarin · Nitrovarfarian · Sinthrome · Acenocumarol · Nicumalon
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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