API reference
Alendronate sodium
- CAS number
- 121268-17-5
- Molecular formula
- C4H18NNaO10P2
- Molecular weight
- 325.12 g/mol
About this molecule
Alendronate is a nitrogen-containing, second generation bisphosphonate. Bisphosphonates were first used to treat Paget's disease in 1971. This class of medications is comprised of inorganic pyrophosphate analogues that contain non-hydrolyzable P-C-P bonds. Similar to other bisphosphonates, alendronate has a high affinity for bone mineral and is taken up during osteoclast resorption. Alendronate inhibits farnesyl pyrophosphate synthetase, one of the enzymes in the mevalonic acid pathway involved in producing isoprenoid compounds that are essential for post-translational modification of small guanosine triphosphate (GTP)-binding proteins, such as Rho, Ras and Rab. Inhibition of this process interferes with osteoclast function and survival. Alendronate is used for the treatment of osteoporosis and Paget's disease.
Source: Toxin and Toxin Target Database (T3DB), via PubChem.
Identifiers
- IUPAC name
- sodium;(4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate;trihydrate
- InChIKey
- DCSBSVSZJRSITC-UHFFFAOYSA-M
- SMILES
- C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.O.O.O.[Na+]
- PubChem CID
- 23681107
Also known as
Alendronate sodium trihydrate · Adronat · Alendros · SODIUM ALENDRONATE TRIHYDRATE · Adrovance · Sodium alendronate · Vantavo · Alendronic acid monosodium salt trihydrate
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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