API reference
AMANTADINE HCl
- CAS number
- 665-66-7
- Molecular formula
- C10H18ClN
- Molecular weight
- 187.71 g/mol
About this molecule
Amantadine Hydrochloride is the hydrochloride salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- adamantan-1-amine;hydrochloride
- InChIKey
- WOLHOYHSEKDWQH-UHFFFAOYSA-N
- SMILES
- C1C2CC3CC1CC(C2)(C3)N.Cl
- PubChem CID
- 64150
Also known as
Amantadine hydrochloride · 1-Adamantanamine hydrochloride · Amantadine HCl · 1-Aminoadamantane hydrochloride · Adamantanamine hydrochloride · Mantadix · 1-Adamantylamine hydrochloride · Osmolex
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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