API reference
Ambrisentan
- CAS number
- 177036-94-1
- Molecular formula
- C22H22N2O4
- Molecular weight
- 378.4 g/mol
About this molecule
Ambrisentan is an orally bioavailable, selective antagonist of the endothelin type-A (ETA) receptor that may be used for the treatment of pulmonary arterial hypertension (PAH). Upon administration, ambrisentan targets and binds to ETA receptor, which prevents the binding of endothelin-1 (ET-1) to the ETA receptor and ET-1/ETA-mediated vasoconstriction and cell proliferation. This may lead to vasodilation. ET-1 concentrations are increased in plasma as well as lung tissue in PAH, and ET-1 may play a key role in the pathogenesis of PAH.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid
- InChIKey
- OUJTZYPIHDYQMC-LJQANCHMSA-N
- SMILES
- CC1=CC(=NC(=N1)O[C@H](C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C
- PubChem CID
- 6918493
Also known as
Ambrisentan · Letairis · Volibris · ambrisentanum · Pulmonext · (S)-ambrisentan · (+)-ambrisentan · (-)-ambrisentan
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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