API reference
Amifostine
- CAS number
- 20537-88-6
- Molecular formula
- C5H15N2O3PS
- Molecular weight
- 214.23 g/mol
About this molecule
Amifostine Anhydrous is a phosphorylated aminosulfhydryl compound with cytoprotective activity. Amifostine is dephosphorylated by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite in the body. The thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 2-(3-aminopropylamino)ethylsulfanylphosphonic acid
- InChIKey
- JKOQGQFVAUAYPM-UHFFFAOYSA-N
- SMILES
- C(CN)CNCCSP(=O)(O)O
- PubChem CID
- 2141
Also known as
amifostine · Ethiofos · Gammaphos · Ethyol · Apaetp · Aminopropylaminoethyl thiophosphate · Ethiofos Anhydrous · Amifostine Anhydrous
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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