API reference
Amiloride
- CAS number
- 2609-46-3
- Molecular formula
- C6H8ClN7O
- Molecular weight
- 229.63 g/mol
About this molecule
Amiloride is a synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels located in the distal tubules and collecting ducts of the kidney, thereby preventing the absorption of sodium and increasing its excretion along with water, to produce naturesis. In response to the hypernatremic conditions in the kidney, the plasma membrane becomes hyperpolarized and electrochemical forces are reduced, which then prevents the excretion of potassium and hydrogen into the lumen.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
- InChIKey
- XSDQTOBWRPYKKA-UHFFFAOYSA-N
- SMILES
- C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N
- Other CAS numbers recorded
- 137053-86-2
- PubChem CID
- 16231
Also known as
AMILORIDE · Amipramidin · Guanamprazin · Amilorida · Amipramizid · 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide · Amiloridum · Midamor
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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