API reference
AMITRIPTYLINE HCl
- CAS number
- 549-18-8
- Molecular formula
- C20H24ClN
- Molecular weight
- 313.9 g/mol
About this molecule
Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity. In the CNS the antinociceptive activity of this agent may involve high affinity binding to and inhibition of N-methyl-D-aspartate (NMDA) receptors and/or the enhancement of the action of serotonin at the spinal terminals of an opioid-mediated intrinsic analgesia system.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine;hydrochloride
- InChIKey
- KFYRPLNVJVHZGT-UHFFFAOYSA-N
- SMILES
- CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
- PubChem CID
- 11065
Also known as
Amitriptyline hydrochloride · Amitriptyline HCl · Etravil · Syneudon · Novoprotect · Amitid · Amitril · Saroten Retard
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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