API reference
Apalutamide
- CAS number
- 956104-40-8
- Molecular formula
- C21H15F4N5O2S
- Molecular weight
- 477.4 g/mol
About this molecule
Apalutamide is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity. Apalutamide binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 4-[7-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide
- InChIKey
- HJBWBFZLDZWPHF-UHFFFAOYSA-N
- SMILES
- CNC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CC(=C(N=C4)C#N)C(F)(F)F)F
- PubChem CID
- 24872560
Also known as
apalutamide · ARN-509 · Erleada · ARN 509 · ARN509 · apalutamida · apalutamidum · L02BB05
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