API reference
Axitinib
- CAS number
- 319460-85-0
- Molecular formula
- C22H18N4OS
- Molecular weight
- 386.5 g/mol
About this molecule
Axitinib is an oral tyrosine kinase inhibitor selective for vascular endothelial growth factor (VEGF) receptors -1, -2 and -3 that is used in the therapy of advanced renal cell carcinoma. Axitinib therapy by itself is commonly associated with transient elevations in serum aminotransferase levels that are generally mild and asymptomatic and has been linked to rare instances of clinically apparent liver injury. When combined with an immune checkpoint inhibitor, as is now common, liver test abnormalities are considerably more frequent and more severe.
Source: LiverTox, via PubChem.
Identifiers
- IUPAC name
- N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
- InChIKey
- RITAVMQDGBJQJZ-FMIVXFBMSA-N
- SMILES
- CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4
- Other CAS numbers recorded
- 1528729-60-3
- PubChem CID
- 6450551
Also known as
Axitinib · Inlyta · axitinibum · L01XE17 · 4agc · Axitinib (Standard) · Inlyta (TN) · 4ag8
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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