API reference
Azacitidine
- CAS number
- 320-67-2
- Molecular formula
- C8H12N4O5
- Molecular weight
- 244.2 g/mol
About this molecule
Azacitidine is a pyrimidine nucleoside analogue of cytidine with antineoplastic activity. Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity. (NCI04)
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
- InChIKey
- NMUSYJAQQFHJEW-KVTDHHQDSA-N
- SMILES
- C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N
- Other CAS numbers recorded
- 1401238-97-8
- PubChem CID
- 9444
Also known as
5-azacytidine · Azacitidine · Azacytidine · Ladakamycin · Mylosar · 5-azacitidine · Azacitidina · Azacitidinum
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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