API reference
Aztreonam
- CAS number
- 78110-38-0
- Molecular formula
- C13H17N5O8S2
- Molecular weight
- 435.4 g/mol
About this molecule
Aztreonam is a monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and death. This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 2-[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoic acid
- InChIKey
- WZPBZJONDBGPKJ-VEHQQRBSSA-N
- SMILES
- C[C@H]1[C@@H](C(=O)N1S(=O)(=O)O)NC(=O)/C(=N\OC(C)(C)C(=O)O)/C2=CSC(=N2)N
- Other CAS numbers recorded
- 149496-40-2
- PubChem CID
- 5742832
Also known as
aztreonam · Azactam · Primbactam · Azthreonam · Nebactam · Azonam · Aztreon · Cayston
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