API reference
Baloxavir marboxil
- CAS number
- 1985606-14-1
- Molecular formula
- C27H23F2N3O7S
- Molecular weight
- 571.6 g/mol
About this molecule
Baloxavir Marboxil is an orally bioavailable prodrug and influenza cap-dependent endonuclease (CEN) inhibitor, with antiviral activity. Upon administration of baloxavir marboxil, the agent is converted by hydrolysis to its active metabolite baloxavir. Baloxavir targets, binds to and inhibits the CEN activity of the influenza polymerase acidic (PA) protein, an influenza virus-specific enzyme in the viral RNA polymerase complex required for the initiation of influenza gene transcription. By inhibiting PA endonuclease, influenza virus mRNA replication is halted. This reduces viral load and prevents further influenza infection.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- [(3R)-2-[(11S)-7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl]-9,12-dioxo-5-oxa-1,2,8-triazatricyclo[8.4.0.03,8]tetradeca-10,13-dien-11-yl]oxymethyl methyl carbonate
- InChIKey
- RZVPBGBYGMDSBG-GGAORHGYSA-N
- SMILES
- COC(=O)OCOC1=C2C(=O)N3CCOC[C@H]3N(N2C=CC1=O)[C@H]4C5=C(CSC6=CC=CC=C46)C(=C(C=C5)F)F
- Other CAS numbers recorded
- 1830312-72-5
- PubChem CID
- 124081896
Also known as
Baloxavir marboxil · Xofluza · baloxavirum marboxilum · J05AX25 · 862-996-0 · baloxavir-marboxil · Xofluza (TN) · Baloxavir marboxil (Standard)
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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