API reference
BENAZEPRIL HCl
- CAS number
- 86541-74-4
- Molecular formula
- C24H29ClN2O5
- Molecular weight
- 460.9 g/mol
About this molecule
Benazepril Hydrochloride is the hydrochloride salt of benazepril, a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, benazepril is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid;hydrochloride
- InChIKey
- VPSRQEHTHIMDQM-FKLPMGAJSA-N
- SMILES
- CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]2CCC3=CC=CC=C3N(C2=O)CC(=O)O.Cl
- Other CAS numbers recorded
- 88372-38-7 · 866541-74-4
- PubChem CID
- 5362123
Also known as
BENAZEPRIL HYDROCHLORIDE · Benazepril HCl · Labopol · Tensanil · Zinadril · Cibace · CARDALIS COMPONENT BENAZEPRIL HYDROCHLORIDE · FORTEKOR PLUS COMPONENT BENAZEPRIL HYDROCHLORIDE
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