API reference
Bosentan
- CAS number
- 147536-97-8
- Molecular formula
- C27H29N5O6S
- Molecular weight
- 551.6 g/mol
About this molecule
Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
- InChIKey
- GJPICJJJRGTNOD-UHFFFAOYSA-N
- SMILES
- CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC
- Other CAS numbers recorded
- 1174918-31-0 · 174227-18-0
- PubChem CID
- 104865
Also known as
Bosentan · Tracleer · bosentan anhydrous · bosentanum · Anhydrous bosentan · C02KX01 · Actelion · Bosentan (INN)
Related entries in the range
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