API reference
Bromocriptine mesylate
- CAS number
- 22260-51-1
- Molecular formula
- C33H44BrN5O8S
- Molecular weight
- 750.7 g/mol
About this molecule
Bromocriptine Mesylate is the mesylate salt of bromocriptine, a semisynthetic ergot alkaloid with dopaminergic, antidyskinetic, and antiprolactinemic activities. Bromocriptine selectively binds to and activates postsynaptic dopamine D2 receptors in the corpus striatum of the central nervous system (CNS). Activation of these D2 receptors activate inhibitory G-proteins, which inhibit adenylyl cyclase, preventing signal transduction mediated via cAMP and resulting in the inhibition of neurotransmission and an antidyskinetic effect. This agent also stimulates dopamine D2 receptors in the anterior pituitary gland, which results in the inhibition of prolactin secretion and lactation and may inhibit the proliferation of prolactin-dependent breast cancer cells.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (6aR,9R)-5-bromo-N-[(1S,2S,4R,7S)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo-4-propan-2-yl-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide;methanesulfonic acid
- InChIKey
- NOJMTMIRQRDZMT-GSPXQYRGSA-N
- SMILES
- CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]3(N1C(=O)[C@](O3)(C(C)C)NC(=O)[C@H]4CN([C@@H]5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O.CS(=O)(=O)O
- PubChem CID
- 31100
Also known as
BROMOCRIPTINE MESYLATE · Bromocriptine mesilate · Pravidel · Cycloset · Bagren · Bromocriptine methanesulfonate · CB-154 mesylate · Cb-154 mesilate
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