API reference
Calcium levofolinate
- CAS number
- 80433-71-2
- Molecular formula
- C20H21CaN7O7
- Molecular weight
- 511.5 g/mol
About this molecule
Levoleucovorin Calcium is a levo isoform of leucovorin calcium with antineoplastic activity. Levoleucovorin is an active metabolite of folic acid, which does not require metabolism by dihydrofolate reductase. This agent counteracts the toxic effects of other folic acid derivative agents, rescuing the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- calcium (2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
- InChIKey
- KVUAALJSMIVURS-QNTKWALQSA-L
- SMILES
- C1[C@@H](N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Ca+2]
- Other CAS numbers recorded
- 2060570-47-8
- PubChem CID
- 135500522
Also known as
LEVOLEUCOVORIN CALCIUM · Elvorine · Calcium levofolinate (6s,l) · CL 307,782 · Folinic acid l-form calcium salt · (-)-5-FORMYL-(6S)-TETRAHYDROFOLATE CALCIUM SALT · CALCIUM LEVOFOLINATE (MART.) · calcium levoleucovorin
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