API reference
Candesartan cilexetil
- CAS number
- 145040-37-5
- Molecular formula
- C33H34N6O6
- Molecular weight
- 610.7 g/mol
About this molecule
Candesartan Cilexetil is a synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
- InChIKey
- GHOSNRCGJFBJIB-UHFFFAOYSA-N
- SMILES
- CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OC(C)OC(=O)OC6CCCCC6
- PubChem CID
- 2540
Also known as
Candesartan cilexetil · Atacand · TCV-116 · Amias · Candesartan 1-(((cyclohexyloxy)carbonyl)oxy)ethyl ester · Ratacand · Parapres · Kenzen
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