API reference
CAPMATINIB HCl
- CAS number
- 1865733-40-9
- Molecular formula
- C23H21Cl2FN6O2
- Molecular weight
- 503.4 g/mol
About this molecule
Capmatinib Hydrochloride is the hydrochloride salt form of capmatinib, an orally bioavailable inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with potential antineoplastic activity. Capmatinib selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide;hydrate;dihydrochloride
- InChIKey
- COWBUPJEEDYWKD-UHFFFAOYSA-N
- SMILES
- CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F.O.Cl.Cl
- PubChem CID
- 122201352
Also known as
Capmatinib hydrochloride · Tabrecta · Capmatinib dihydrochloride monohydrate · Capmatinib hydrochloride hydrate · Capmatinib 2HCl.H2O · Capmatinib dihydrochloride hydrate · Capmatinib 2HCl hydrate · Capmatinib (dihydrochloride hydrate)
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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