API reference
Carbidopa
- CAS number
- 28860-95-9
- Molecular formula
- C10H14N2O4
- Molecular weight
- 226.23 g/mol
About this molecule
Carbidopa presents a chemical denomination of N-amino-alpha-methyl-3-hydroxy-L-tyrosine monohydrate. It potently inhibits aromatic amino acid decarboxylase (DDC) and due to its chemical properties, it does not cross the blood-brain barrier. Due to its activity, carbidopa is always administered concomitantly with [levodopa]. An individual formulation containing solely carbidopa was generated to treat nausea in patients where the combination therapy [levodopa]/carbidopa is not efficient reducing nausea. The first approved product by the FDA containing only carbidopa was developed by Amerigens Pharmaceuticals Ltd and approved on 2014. On the other hand, the combination treatment of carbidopa/levodopa was originally developed by Watson Labs but the historical information by the FDA brings back to the approval of this combination therapy developed by Mayne Pharma in 1992.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
- InChIKey
- TZFNLOMSOLWIDK-JTQLQIEISA-N
- SMILES
- C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)NN
- Other CAS numbers recorded
- 1426847-87-1
- PubChem CID
- 34359
Also known as
carbidopa · Lodosyn · Carbidopa anhydrous · N-Aminomethyldopa · (S)-(-)-carbidopa · alpha-Methyldopahydrazine · Carbidopum · L-alpha-Methyldopahydrazine
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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