API reference
Chlorthalidone
- CAS number
- 77-36-1
- Molecular formula
- C14H11ClN2O4S
- Molecular weight
- 338.8 g/mol
About this molecule
Chlorthalidone is a long acting thiazide-like diuretic of the sulfamoylbenzamide class that is devoid of the benzothiadiazine structure. Chlorthalidone directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment in the distal convoluted tubule (DCT) in the kidney. This leads to an increase in sodium, chloride, bicarbonate, and potassium secretion resulting in the excretion of water. In addition, this agent, like other thiazide diuretics, decreases calcium and uric acid secretion. In addition, this agent inhibits many carbonic anhydrase (CA) isoenzymes. Chlorthalidone is used in the treatment of high blood pressure, edema and congestive heart failure. The elimination half-life is about 40 to 50 hours.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide
- InChIKey
- JIVPVXMEBJLZRO-UHFFFAOYSA-N
- SMILES
- C1=CC=C2C(=C1)C(=O)NC2(C3=CC(=C(C=C3)Cl)S(=O)(=O)N)O
- Other CAS numbers recorded
- 74658-80-3
- PubChem CID
- 2732
Also known as
chlorthalidone · Chlortalidone · Phthalamudine · Hygroton · Chlorphthalidolone · Chlorthalidon · Natriuran · Phthalamodine
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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