API reference
Chlorzoxazone
- CAS number
- 95-25-0
- Molecular formula
- C7H4ClNO2
- Molecular weight
- 169.56 g/mol
About this molecule
Chlorzoxazone is a benzoxazolone derivative with mild sedative and centrally-acting muscle relaxant activities. Although its exact mechanism of action is unknown, chlorzoxazone (CZ) appears to act at the spinal cord and subcortical levels of the brain to inhibit multisynaptic reflex arcs involved in producing and maintaining muscle spasms. This agent is extensively hydroxylated by cytochrome P450 2E1 (CYP2E1) to 6-hydroxychlorzoxazone (HCZ),11,12 which is subsequently glucuronidated and eliminated renally. Highly selective for CYP2E1, CZ may be used as a selective probe for phenotyping CYP2E1 in humans; the ratio of HCZ-to-CZ plasma concentrations obtained 2 to 4 hours after oral administration of CZ may be used as a phenotypic measure of CYP2E1 enzymatic activity.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 5-chloro-3H-1,3-benzoxazol-2-one
- InChIKey
- TZFWDZFKRBELIQ-UHFFFAOYSA-N
- SMILES
- C1=CC2=C(C=C1Cl)NC(=O)O2
- PubChem CID
- 2733
Also known as
chlorzoxazone · Paraflex · 5-Chloro-2(3H)-benzoxazolone · 5-Chloro-2-benzoxazolone · 2(3H)-Benzoxazolone, 5-chloro- · 5-Chloro-2-benzoxazolinone · 5-Chlorobenzoxazolidone · Parafon Forte DSC
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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