API reference
CINACALCET HCl
- CAS number
- 364782-34-3
- Molecular formula
- C22H23ClF3N
- Molecular weight
- 393.9 g/mol
About this molecule
Cinacalcet Hydrochloride is the orally bioavailable hydrochloride salt of the calcimimetic cinacalcet. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels. In addition, by reducing PTH levels, cinacalcet may reduce PSA levels; PTH appears to raise PSA levels and may increase prostate cancer cell growth.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine;hydrochloride
- InChIKey
- QANQWUQOEJZMLL-PKLMIRHRSA-N
- SMILES
- C[C@H](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl
- PubChem CID
- 156418
Also known as
Cinacalcet hydrochloride · Cinacalcet HCl · Mimpara · AMG073 HCl · AMG-073 HCL · AMG073 hydrochloride · 620-490-5 · Sensipar
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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