API reference
Cladribine
- CAS number
- 4291-63-8
- Molecular formula
- C10H12ClN5O3
- Molecular weight
- 285.69 g/mol
About this molecule
Cladribine is a purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04)
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
- InChIKey
- PTOAARAWEBMLNO-KVQBGUIXSA-N
- SMILES
- C1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O
- Other CAS numbers recorded
- 24757-90-2
- PubChem CID
- 20279
Also known as
Cladribine · 2-Chloro-2'-deoxyadenosine · Leustatin · 2-Chlorodeoxyadenosine · 2-CdA · Chlorodeoxyadenosine · Litak · ADENOSINE, 2-CHLORO-2'-DEOXY-
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