API reference
Clobazam
- CAS number
- 22316-47-8
- Molecular formula
- C16H13ClN2O2
- Molecular weight
- 300.74 g/mol
About this molecule
Clobazam is a 1,5-benzodiazepine and partial gamma-aminobutyric acid (GABA) receptor agonist, with anxiolytic, sedative, and anticonvulsant activities. Clobazam binds to a specific site, distinct from the inhibitory neurotransmitter GABA binding site, on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the opening of chloride-channels. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and a decrease in neuronal excitability.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 7-chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione
- InChIKey
- CXOXHMZGEKVPMT-UHFFFAOYSA-N
- SMILES
- CN1C(=O)CC(=O)N(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
- PubChem CID
- 2789
Also known as
Clobazam · Frisium · Urbanyl · Clorepin · Urbadan · Onfi · Mystan · HR 376
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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