API reference
Clofarabine
- CAS number
- 123318-82-1
- Molecular formula
- C10H11ClFN5O3
- Molecular weight
- 303.68 g/mol
About this molecule
Clofarabine is a purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia. It has a role as an antimetabolite and an antineoplastic agent. It is a member of adenosines and an organofluorine compound.
Source: ChEBI, via PubChem.
Identifiers
- IUPAC name
- (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
- InChIKey
- WDDPHFBMKLOVOX-AYQXTPAHSA-N
- SMILES
- C1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F)Cl)N
- PubChem CID
- 119182
Also known as
Clofarabine · Clolar · Evoltra · Clofarex · Cl-F-Ara-A · CAFdA · clofarabina · clofarabinum
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
Tell us the grade, the quantity and the market.
Send the molecule or ingredient, the specification and the destination. We reply from Tehran with the questions, the documents and the next step.