API reference
Clonidine
- CAS number
- 4205-90-7
- Molecular formula
- C9H9Cl2N3
- Molecular weight
- 230.09 g/mol
About this molecule
Clonidine is an imidazoline derivate and centrally-acting alpha-adrenergic agonist, with antihypertensive activity. Clonidine binds to and stimulates central alpha-2 adrenergic receptors, thereby reducing the amount of norepinephrine (NE) release and thus decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate. In addition, clonidine binds to imidazoline receptor subtype 1 (I1), which may also contribute to a reduction in blood pressure.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
- InChIKey
- GJSURZIOUXUGAL-UHFFFAOYSA-N
- SMILES
- C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl
- PubChem CID
- 2803
Also known as
clonidine · Clonidin · N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine · Chlornidinum · Catapres-TTS · ST-155-BS · Catapresan · Catapressan
Related entries in the range
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