API reference
Crisaborole
- CAS number
- 906673-24-3
- Molecular formula
- C14H10BNO3
- Molecular weight
- 251.05 g/mol
About this molecule
Crisaborole is a novel oxaborole approved by FDA on December 14, 2016 as Eucrisa, a topical treatment of for mild to moderate atopic dermatitis. This non-steroidal agent is efficacious in improving disease severity, reducing the risk of infection and reducing the signs and symptoms in patients 2 years old and older. It reduces the local inflammation in the skin and prevents further exacerbation of the disease with a good safety profile. Its structure contains a boron atom, which facilitates skin penetration and binding to the bimetal center of the phosphodiesterase 4 enzyme. It is currently under development as topical treatment of psoriasis.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- 4-[(1-hydroxy-3H-2,1-benzoxaborol-5-yl)oxy]benzonitrile
- InChIKey
- USZAGAREISWJDP-UHFFFAOYSA-N
- SMILES
- B1(C2=C(CO1)C=C(C=C2)OC3=CC=C(C=C3)C#N)O
- Other CAS numbers recorded
- 1073669-75-6
- PubChem CID
- 44591583
Also known as
Crisaborole · Eucrisa · Staquis · crisaborol · Crisaborole topical ointment 2% · crisaborolum · 4-((1-hydroxy-3H-2,1-benzoxaborol-5-yl)oxy)benzonitrile · D11AH06
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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