API reference
Dapagliflozin
- CAS number
- 461432-26-8
- Molecular formula
- C21H25ClO6
- Molecular weight
- 408.9 g/mol
About this molecule
Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tubule of the nephron and causing glycosuria. Dapagliflozin has been investigated either as monotherapy or as an adjunct treatment with insulin or other oral hypoglycemic agents. Dapagliflozin was originally approved by the FDA on Jan 08, 2014, to improve glycemic control in adults with type 2 diabetes in conjunction with diet and exercise. It was later approved to reduce the risk of kidney function decline, kidney failure, cardiovascular death, and hospitalization for heart failure in adults with chronic kidney disease in April 2021.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- (2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
- InChIKey
- JVHXJTBJCFBINQ-ADAARDCZSA-N
- SMILES
- CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)Cl
- PubChem CID
- 9887712
Also known as
Dapagliflozin · Forxiga · dapagliflozine · Dapagliflozina · dapagliflozinum · LYN-045 · DAPAGLIFLOZIN COMPONENT QTERNMET · QTERNMET XR COMPONENT DAPAGLIFLOZIN
Related entries in the range
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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