API reference
Dapsone
- CAS number
- 80-08-0
- Molecular formula
- C12H12N2O2S
- Molecular weight
- 248.3 g/mol
About this molecule
Dapsone is a synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 4-(4-aminophenyl)sulfonylaniline
- InChIKey
- MQJKPEGWNLWLTK-UHFFFAOYSA-N
- SMILES
- C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N
- PubChem CID
- 2955
Also known as
dapsone · 4,4'-Sulfonyldianiline · Diaphenylsulfone · 4,4'-Diaminodiphenyl sulfone · Dapson · Diphenasone · 4,4'-Diaminodiphenylsulfone · Disulone
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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