API reference
Dasatinib
- CAS number
- 302962-49-8
- Molecular formula
- C22H26ClN7O2S
- Molecular weight
- 488 g/mol
About this molecule
Dasatinib Anhydrous is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
- InChIKey
- ZBNZXTGUTAYRHI-UHFFFAOYSA-N
- SMILES
- CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO
- PubChem CID
- 3062316
Also known as
Dasatinib · Sprycel · Dasatinib anhydrous · Dasatinib (anhydrous) · dasatinibum · anh. dasatinib · anhydrous dasatinib · dasatinib (anh.)
Related entries in the range
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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