API reference
Diclofenac
- CAS number
- 15307-86-5
- Molecular formula
- C14H11Cl2NO2
- Molecular weight
- 296.1 g/mol
About this molecule
Diclofenac is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. This agent also may inhibit COX-2-mediated tumor angiogenesis. When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs. (NCI04)
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 2-[2-(2,6-dichloroanilino)phenyl]acetic acid
- InChIKey
- DCOPUUMXTXDBNB-UHFFFAOYSA-N
- SMILES
- C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl
- Other CAS numbers recorded
- 128402-48-2
- PubChem CID
- 3033
Also known as
diclofenac · Diclofenac acid · 2-(2-((2,6-Dichlorophenyl)amino)phenyl)acetic acid · Diclofenac free acid · Diclofenaco · Diclophenac · Diclofenacum · Zorvolex
Related entries in the range
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