API reference
Diflunisal
- CAS number
- 22494-42-4
- Molecular formula
- C13H8F2O3
- Molecular weight
- 250.2 g/mol
About this molecule
Diflunisal is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. Diflunisal competitively inhibits both cyclooxygenase (COX) -1 and -2, with higher affinity for COX-1, and subsequently blocks the conversion of arachidonic acid to prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. Diflunisal differs from other salicylates, in that it is not metabolized to salicylic acid, hence it has a longer half-life.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 5-(2,4-difluorophenyl)-2-hydroxybenzoic acid
- InChIKey
- HUPFGZXOMWLGNK-UHFFFAOYSA-N
- SMILES
- C1=CC(=C(C=C1C2=C(C=C(C=C2)F)F)C(=O)O)O
- PubChem CID
- 3059
Also known as
diflunisal · Dolobid · Dolobis · Flovacil · 5-(2,4-Difluorophenyl)salicylic acid · 5-(2,4-difluorophenyl)-2-hydroxybenzoic acid · Diflunisalum · 2',4'-Difluoro-4-hydroxy-3-biphenylcarboxylic acid
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