API reference
Difluprednate
- CAS number
- 23674-86-4
- Molecular formula
- C27H34F2O7
- Molecular weight
- 508.5 g/mol
About this molecule
Difluprednate is a topical corticosteroid and prednisolone acetate derivative, with anti-inflammatory activity. Upon instillation into the eye, difluprednate binds to and activates the glucocorticoid receptor (GR). The receptor-ligand complex binds to promoter regions of certain genes and initiates RNA transcription. This results in an induction of synthesis of phospholipase A2 inhibitory proteins, thereby inhibiting the synthesis of arachidonic acid and preventing the synthesis of certain inflammatory mediators, such as prostaglandins and leukotrienes. This reduces ocular inflammation and pain.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
- InChIKey
- WYQPLTPSGFELIB-JTQPXKBDSA-N
- SMILES
- CCCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C(=O)COC(=O)C
- PubChem CID
- 443936
Also known as
difluprednate · Durezol · DFBA · Difluprednato · Epitopic · Difluoroprednisolone butyrate acetate · Difluprednatum · 6-alpha,9-alpha-Difluoroprednisolone 17-butyrate 21-acetate
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