API reference
Dimethyl fumarate
- CAS number
- 624-49-7
- Molecular formula
- C6H8O4
- Molecular weight
- 144.12 g/mol
About this molecule
Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. Dimethyl fumarate is marketed under the brand name Tecfidera, and it was the third oral disease-modifying agent for multiple sclerosis approved by the FDA, following [fingolimod] and [teriflunomide]. Prior to its FDA approval, dimethyl fumarate had been used in Germany for treatment of psoriasis.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- dimethyl (E)-but-2-enedioate
- InChIKey
- LDCRTTXIJACKKU-ONEGZZNKSA-N
- SMILES
- COC(=O)/C=C/C(=O)OC
- Other CAS numbers recorded
- 23055-10-9 · 12287-98-8
- PubChem CID
- 637568
Also known as
Dimethyl fumarate · Tecfidera · Fumaric acid dimethyl ester · Fumaderm · Dimethylfumarate · Fumaric acid, dimethyl ester · BG-12 · Panaclar
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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