API reference
Dofetilide
- CAS number
- 115256-11-6
- Molecular formula
- C19H27N3O5S2
- Molecular weight
- 441.6 g/mol
About this molecule
Dofetilide is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide
- InChIKey
- IXTMWRCNAAVVAI-UHFFFAOYSA-N
- SMILES
- CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C
- PubChem CID
- 71329
Also known as
Dofetilide · Tikosyn · Dofetilida · Dofetilidum · UK-68,798 · 1-MSPMPE · Dofetilide 0.5mg · DOFETILDE
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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