API reference
DOXEPIN HCl
- CAS number
- 1229-29-4
- Molecular formula
- C19H22ClNO
- Molecular weight
- 315.8 g/mol
About this molecule
Doxepin Hydrochloride is a dibenzoxepin derivative and tricyclic antidepressant with antipruritic and sedative activities. Doxepin blocks the reuptake of norepinephrine and serotonin into presynaptic terminals thereby prolonging the availability of the monoaminergic neurotransmitters within the synaptic cleft and enhancing their action leading to sedative effects. Doxepin also has antagonistic effects on histamine (H1 and H2), 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is the result mediated through inhibition of histamine receptors.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (3E)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride
- InChIKey
- MHNSPTUQQIYJOT-SJDTYFKWSA-N
- SMILES
- CN(C)CC/C=C/1\C2=CC=CC=C2COC3=CC=CC=C31.Cl
- Other CAS numbers recorded
- 4698-39-9
- PubChem CID
- 6419921
Also known as
Doxepin Hydrochloride · Doxepin HCl · Adapin · Silenor · Doxepn Hydrochloride · Hydrochloride, Doxepin · 214-966-8 · (e)-doxepin hydrochloride
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