API reference
Encorafenib
- CAS number
- 1269440-17-6
- Molecular formula
- C22H27ClFN7O4S
- Molecular weight
- 540 g/mol
About this molecule
Encorafenib is an orally available Raf kinase inhibitor with potential antineoplastic activity. Encorafenib specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- methyl N-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate
- InChIKey
- CMJCXYNUCSMDBY-ZDUSSCGKSA-N
- SMILES
- C[C@@H](CNC1=NC=CC(=N1)C2=CN(N=C2C3=C(C(=CC(=C3)Cl)NS(=O)(=O)C)F)C(C)C)NC(=O)OC
- PubChem CID
- 50922675
Also known as
Encorafenib · LGX818 · LGX-818 · Braftovi · LGX 818 · encorafenibum · L01XE46 · Encorafenib (LGX818)
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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