API reference
Entecavir hydrate
- CAS number
- 209216-23-9
- Molecular formula
- C12H17N5O4
- Molecular weight
- 295.29 g/mol
About this molecule
Entecavir hydrate is the monohydrate form of entecavir. A synthetic analogue of 2'-deoxyguanosine, entecavir is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. It is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. Enteclavir is used for the treatment of chronic hepatitis B. It has a role as an antiviral drug and an EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor. It contains an entecavir (anhydrous).
Source: ChEBI, via PubChem.
Identifiers
- IUPAC name
- 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1H-purin-6-one;hydrate
- InChIKey
- YXPVEXCTPGULBZ-WQYNNSOESA-N
- SMILES
- C=C1[C@H](C[C@@H]([C@H]1CO)O)N2C=NC3=C2N=C(NC3=O)N.O
- PubChem CID
- 135526609
Also known as
Entecavir hydrate · entecavir monohydrate · Entecavir hydrate (JAN) · Entecavir (USP) · Entecavir (monohydrate) · Baraclude (TN) · Baraclud · Entecavir Monohydrate?
Related entries in the range
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