API reference
ERLOTINIB HCl
- CAS number
- 183319-69-9
- Molecular formula
- C22H24ClN3O4
- Molecular weight
- 429.9 g/mol
About this molecule
Erlotinib Hydrochloride is the hydrochloride salt of a quinazoline derivative with antineoplastic properties. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine;hydrochloride
- InChIKey
- GTTBEUCJPZQMDZ-UHFFFAOYSA-N
- SMILES
- COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl
- PubChem CID
- 176871
Also known as
Erlotinib hydrochloride · erlotinib HCl · Tarceva · OSI-774 · OSI 774 · HCl, Erlotinib · 11C erlotinib · CP-358,774-01
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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