API reference
Ertapenem sodium
- CAS number
- 153773-82-1
- Molecular formula
- C22H24N3NaO7S
- Molecular weight
- 497.5 g/mol
About this molecule
Ertapenem Sodium is the sodium salt of ertapenem, a 1-beta-methyl carbapenem and a broad-spectrum beta-lactam antibiotic with bactericidal activity. Ertapenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, in particular PBPs 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Inhibition of peptidoglycan synthesis results in weakening and lysis of the cell wall and cell death. In vitro, this agent has shown activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Erapenem is resistant to hydrolysis by a variety of beta-lactamases, including penicillinases, cephalosporinases and extended-spectrum beta-lactamases.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- sodium 3-[[(2S,4S)-4-[[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]sulfanyl]pyrrolidine-2-carbonyl]amino]benzoate
- InChIKey
- ZXNAQFZBWUNWJM-HRXMHBOMSA-M
- SMILES
- C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H](NC3)C(=O)NC4=CC=CC(=C4)C(=O)[O-])C(=O)O)[C@@H](C)O.[Na+]
- PubChem CID
- 23674512
Also known as
Ertapenem sodium · Ertapenem sodium salt · Invanz · Invanz (TN) · Ertapenem sodium (USAN) · MK-826 · Ertapenem Sodium?
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