API reference
Esomeprazole magnesium
- CAS number
- 161973-10-0
- Molecular formula
- C34H36MgN6O6S2
- Molecular weight
- 713.1 g/mol
About this molecule
Esomeprazole Magnesium is the magnesium salt of esomeprazole, the S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulphenamide; the active sulphenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- magnesium bis(5-methoxy-2-[(S)-(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]benzimidazol-1-ide)
- InChIKey
- KWORUUGOSLYAGD-YPPDDXJESA-N
- SMILES
- CC1=CN=C(C(=C1OC)C)C[S@](=O)C2=NC3=C([N-]2)C=CC(=C3)OC.CC1=CN=C(C(=C1OC)C)C[S@](=O)C2=NC3=C([N-]2)C=CC(=C3)OC.[Mg+2]
- PubChem CID
- 9568613
Also known as
Esomeprazole magnesium · Nexium 24hr · Esomeprazole Dr · Nexium 24HR ClearMinis · Esomeprazole Magnesium DR · Esomeprazole Magnesium D/r · Esomeprazole Magnesium Delayed-Release 20 mg mini · Esomeprazole Magnesium Delayed-Release Capsules, 20 mg
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