API reference
Ezetimibe
- CAS number
- 163222-33-1
- Molecular formula
- C24H21F2NO3
- Molecular weight
- 409.4 g/mol
About this molecule
Ezetimibe is an azetidinone derivative and a cholesterol absorption inhibitor with lipid-lowering activity. Ezetimibe appears to interact physically with cholesterol transporters at the brush border of the small intestine and inhibits the intestinal absorption of cholesterol and related phytosterols. As a result, ezetimibe causes a decrease in the level of blood cholesterol or an increase in the clearance of cholesterol from the bloodstream. Overall, the following effects observed are a reduction of hepatic cholesterol stores and a reduction of total cholesterol, LDL cholesterol, and other triglycerides in the blood.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
- InChIKey
- OLNTVTPDXPETLC-XPWALMASSA-N
- SMILES
- C1=CC(=CC=C1[C@@H]2[C@H](C(=O)N2C3=CC=C(C=C3)F)CC[C@@H](C4=CC=C(C=C4)F)O)O
- Other CAS numbers recorded
- 947332-80-1
- PubChem CID
- 150311
Also known as
Ezetimibe · Zetia · Ezetrol · Ezedoc · ezetimib · ezetimiba · ezetimibum · ROSZET COMPONENT EZETIMIBE
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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