API reference
Felodipine
- CAS number
- 72509-76-3
- Molecular formula
- C18H19Cl2NO4
- Molecular weight
- 384.2 g/mol
About this molecule
Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- 5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- InChIKey
- RZTAMFZIAATZDJ-UHFFFAOYSA-N
- SMILES
- CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C
- Other CAS numbers recorded
- 119945-59-4 · 1217744-87-0 · 1217716-73-8
- PubChem CID
- 3333
Also known as
felodipine · Plendil · Flodil · Modip · Felodipina · Preslow · Felodipinum · Felo Puren
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