API reference
Fentanyl
- CAS number
- 437-38-7
- Molecular formula
- C22H28N2O
- Molecular weight
- 336.5 g/mol
About this molecule
Fentanyl is a synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to and activates the mu-receptor in the central nervous system (CNS) thereby mimicking the effects of endogenous opiates. Activation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This causes a decrease in intracellular cAMP which inhibits cAMP-mediated calcium influx into the cell via the calcium channels and thereby results in hyperpolarization and reduced neuronal excitability.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
- InChIKey
- PJMPHNIQZUBGLI-UHFFFAOYSA-N
- SMILES
- CCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3
- Other CAS numbers recorded
- 201415-26-1
- PubChem CID
- 3345
Also known as
fentanyl · Phentanyl · Fentanil · Fentanest · Duragesic · Sublimase · Fentanylum · Durogesic
Related entries in the range
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