API reference
Flucytosine
- CAS number
- 2022-85-7
- Molecular formula
- C4H4FN3O
- Molecular weight
- 129.09 g/mol
About this molecule
Flucytosine is only found in individuals that have used or taken this drug. It is a fluorinated cytosine analog that is used as an antifungal agent. [PubChem]Although the exact mode of action is unknown, it has been proposed that flucytosine acts directly on fungal organisms by competitive inhibition of purine and pyrimidine uptake and indirectly by intracellular metabolism to 5-fluorouracil. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. It also appears to be an inhibitor of fungal thymidylate synthase.
Source: Toxin and Toxin Target Database (T3DB), via PubChem.
Identifiers
- IUPAC name
- 6-amino-5-fluoro-1H-pyrimidin-2-one
- InChIKey
- XRECTZIEBJDKEO-UHFFFAOYSA-N
- SMILES
- C1=NC(=O)NC(=C1F)N
- Other CAS numbers recorded
- 117969-88-7 · 130256-61-0 · 124356-72-5
- PubChem CID
- 3366
Also known as
5-Fluorocytosine · flucytosine · Ancobon · Fluorocytosine · Ancotil · Fluocytosine · 5-Fluorocystosine · Flucytosin
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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