API reference
Fludrocortisone acetate
- CAS number
- 514-36-3
- Molecular formula
- C23H31FO6
- Molecular weight
- 422.5 g/mol
About this molecule
Fludrocortisone Acetate is the acetate salt of a synthetic fluorinated corticosteroid with antiinflammatory and antiallergic activities. As a glucocorticoid-receptor agonist, fludrocortisone binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- [2-[(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
- InChIKey
- SYWHXTATXSMDSB-GSLJADNHSA-N
- SMILES
- CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)CC[C@@]43C)F)O)C)O
- PubChem CID
- 225609
Also known as
FLUDROCORTISONE ACETATE · Scherofluron · Alflorone acetate · Florinef acetate · Fludrocortisone 21-acetate · Cortef-F · Fluorocortisol acetate · Fluorocortisone acetate
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