API reference
Fluorouracil
- CAS number
- 51-21-8
- Molecular formula
- C4H3FN2O2
- Molecular weight
- 130.08 g/mol
About this molecule
Fluorouracil is an antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 5-fluoro-1H-pyrimidine-2,4-dione
- InChIKey
- GHASVSINZRGABV-UHFFFAOYSA-N
- SMILES
- C1=C(C(=O)NC(=O)N1)F
- Other CAS numbers recorded
- 191047-65-1 · 191047-64-0 · 191115-88-5 · 1004-03-1
- PubChem CID
- 3385
Also known as
5-Fluorouracil · fluorouracil · Efudex · Fluracil · Fluoroblastin · Queroplex · Carzonal · Fluril
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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